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Bessie by Nick Penn is another comic strip obscurity that I couldn't find much information on. It was originally titled "Uncle Dudley," who I assume is the "Unk" trying to carry all of the packages in this example. It seems to take several cues from Nancy, being about a little girl that lives with a glamorous woman (Lana Jane), has a friend "from the wrong side of the tracks (Orson)," and who is a bit tomboyish The characters may potentially have been pulled from real life, or perhaps just the names, given that Penn's sister's name was Bessie, and Orson's last name was Pouletsopoulos, which sounds similar to Penn's real last name, Pouletsos. It ran from 1946-1948 under its original name, and from 1948-1950 as Bessie.
It's interesting that Bessie has her own half-door that she can use to go in and out of the house. I wonder why a child small enough that she can't reach the doorknob of a regular door would need to go out so much on her own. But then again, I never really understood how that worked with Nancy either. She always seems to be going all kinds of places on her own without her aunt Fritzi. Those were different times, I guess.