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A few years ago, I posted an Off the Record comic during December, which caused confusion when I looked up information about its creators. A certain trusted source, Lambiek Comiclopedia, listed Carl Kuhn as the creator of the strip in 1935, which Ed Reed took over at a later time. It doesn't say when he took it over, but seeing as today's strip is from 1938 and is credited to Ed Reed, it couldn't have been that long after it debuted. I have a feeling that Lambiek may be incorrect. I guess I'll have to do further research...
That aside, one of the strips within the strip was "The Three Bares," which featured the three babies seen here as recurring characters. I think it's a clever idea to place the "Do Not Open Until Christmas" sign on the castor oil, but it may end up backfiring on them. If they have to take that on Christmas, it may not end up being so merry.